{"id":549,"date":"2014-08-14T17:51:52","date_gmt":"2014-08-14T17:51:52","guid":{"rendered":"http:\/\/www.indianbodybuilding.co.in\/Articles\/?p=549"},"modified":"2014-08-14T17:51:52","modified_gmt":"2014-08-14T17:51:52","slug":"stay-anabolic","status":"publish","type":"post","link":"https:\/\/www.indianbodybuilding.co.in\/Articles\/stay-anabolic\/","title":{"rendered":"How to stay Anabolic"},"content":{"rendered":"<div class=\"wp-caption alignleft\" ><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- Main_336x280 -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:inline-block;width:336px;height:280px\"\r\n     data-ad-client=\"ca-pub-3247500487073208\"\r\n     data-ad-slot=\"9364966176\"><\/ins>\r\n<script>\r\n(adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><\/div>A while back I came across a study looking at different protein feeding patterns. The researchers had one group drink 10 g of protein every 1.5 hours. Another group drank 20 g every three hours. A third group drank 40 g every six hours. All groups drank the same amount of whey protein (80 g) over the 12-hour study period. In their experiment, the group that drank 20 g every three hours produced the greatest anabolic response. The results didn\u2019t surprise me because previous studies have shown 20 g of whey protein to maximally stimulate protein synthesis. What confused me was the seemingly poor response to 40 g of whey. I would have thought 40 g would\u2019ve produced a strong anabolic response with blood amino acid levels not returning to baseline for six hours. Part of my confusion may have been caused by the authors of this study suggesting some sort of desensitisation to high amino acid levels. This was in line with another theory previously put out by some researchers that there is a \u201cmuscle full\u201d effect where despite high levels of amino acids, the cell stops synthesising muscle protein. This did not bode well for folks like me who consume in excess of 300 g of protein per day. Every meal I eat has at least 40 g of protein.<\/p>\n<p> Then a group at Rutgers University in New Jersey changed my thinking on the issue of desensitisation. They acknowledged that post-meal muscle protein synthesis (MPS) increased rapidly with peak values around 90 minutes and a decline to pre-meal baseline by 180 minutes. The response of muscle tissue was difficult to explain with rapid initiation of MPS associated with increased circulating amino acids, however, the decline in MPS at 180 minutes post-meal occurred with plasma leucine levels still elevated and initiation factors still activated. Everything about the cell and its environment was primed for protein synthesis, but by 180 minutes, everything just stops. The Rutgers researchers were able to show that the problem lies in the cells\u2019 energy status and a process called elongation. Considering that whole body protein turnover accounts for more than one quarter of resting energy expenditure and that assembling amino acids into protein chains (i.e., elongation) accounts for more than 99% of that energy expenditure, it\u2019s logical that skeletal muscle would shut down protein synthesis to prevent cellular energy depletion. Not only did this study identify the problem, it also showed that there is a solution, literally. A solution of leucine and\/or carbohydrates given between meals is able to restore the energy status of muscle cells and prolong protein synthesis far beyond 180 minutes. So in order to stay anabolic between big meals, prepare a mixture of 5 g leucine and 15\u201330 g carbs (e.g., waxy maize) and drink it two hours after your meal. If possible, using BCAAs instead of straight leucine may produce a better effect as BCAAs have been shown to deplete during protein synthesis.<br \/>\n<div class=\"e3lan e3lan-in-post2\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- Below Header -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:inline-block;width:728px;height:90px\"\r\n     data-ad-client=\"ca-pub-3247500487073208\"\r\n     data-ad-slot=\"5121188972\"><\/ins>\r\n<script>\r\n(adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><\/div>\nThe next HOT bodybuilding supplement<\/p>\n<p>Resistance training creates a unique and powerful anabolic signal in muscle tissue. In muscle cells, the ability to perceive and respond to resistance<br \/>\ntraining is called mechanoperception. This process of converting the mechanical forces of lifting a weight into the biochemical signals that lead to<br \/>\nhypertrophy is called mechanotransduction. Muscle cells, in turn, are called mechanocytes. This simply means that muscle cells have the ability to<br \/>\nsense mechanical load and convert it into biochemical signals that regulate protein synthesis.<br \/>\nYou may have heard of capsaicin. It\u2019s the stuff in chilli peppers that makes them hot. I know what you\u2019re thinking; what do chilli peppers have to do with mechano-what-cha-ma-call-it? Nothing, or at least that\u2019s what I thought until I found a recent study looking at the effects of capsaicin on anabolic signalling in muscle cells. The authors were able to show that load-induced activation of the capsaicin receptor (TRPV1) in muscle cells caused an increase in intracellular calcium ion concentrations and that this activated mTOR and promoted muscle hypertrophy. Now, all you need to know about mTOR is that it\u2019s the key signalling pathway responsible for initiating muscle growth. Normally, weight training causes an increase in intracellular calcium ion levels<br \/>\nand this contributes to the activation of the mTOR pathway. Before you run out and buy a bunch of cayenne supplements (like I did) be aware that some people can\u2019t stomach cayenne. It can cause the sensation of heartburn that can be quite uncomfortable. Other people have no problem with it.<br \/>\nUntil now, no food supplement has been shown to have the ability to mimic weight training in muscle cells. Creatine, as we all know, can support muscle gains by improving cellular energy status as well as activating muscle satellite cells, but this can hardly be considered mimicking weight training.<br \/>\nEssential amino acids, and particularly leucine, can trigger protein synthesis, but it doesn\u2019t alter calcium ion levels like weightlifting. Ursolic acid is another recently discovered activator of anabolic pathways in muscle cells. Ursolic acid can increase Akt activity, blood vessel recruitment and autocrine\/paracrine<br \/>\nIGF-I signalling in muscle cells. This is very impressive yet still slightly different from the mechanism of capsaicin. Finally, even phosphatidic acid which has recently been shown to directly activate mTOR is acting in a different way than capsaicin. The reason I\u2019m trying to point out the differences in the mechanisms of each of these nutritional substances is that there may be potential synergism if one were to use each of them strategically together. Creatine, L-leucine, and phosphatidic acid have both been shown independently to improve gains in muscle mass in humans. Ursolic acid, and now capsaicin, have now been shown to increase muscle mass in animals. The plausibility of real anabolic effects in humans is good.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A while back I came across a study looking at different protein feeding patterns. The researchers had one group drink 10 g of protein every 1.5 hours. Another group drank 20 g every three hours. A third group drank 40 g every six hours. All groups drank the same amount of whey protein (80 g) &hellip;<\/p>\n","protected":false},"author":1,"featured_media":551,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[43],"tags":[],"class_list":["post-549","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-nutrition"],"_links":{"self":[{"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/posts\/549","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/comments?post=549"}],"version-history":[{"count":0,"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/posts\/549\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/media\/551"}],"wp:attachment":[{"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/media?parent=549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/categories?post=549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.indianbodybuilding.co.in\/Articles\/wp-json\/wp\/v2\/tags?post=549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}